PROTONIX® I.V. (pantoprazole sodium) for Injection. Rx only. DESCRIPTION. The active ingredient in PROTONIX ® I.V. (pantoprazole sodium) for Injection is a substituted INDICATIONS Gastroesophageal Reflux Disease Associated With A History Of Erosive Esophagitis. PROTONIX I.V. for Injection is indicated for short-term treatment (7 to 10 days) of adult patients with gastroesophageal reflux disease and a history of erosive esophagitis. Easy-to-read patient leaflet for Pantoprazole Injection. Includes indications, proper use, special instructions, precautions, and possible side effects. Includes indications, proper use, special instructions, precautions, and possible side effects. Gastroesophageal Reflux Disease Associated with a History of Erosive Esophagitis. Pantoprazole Sodium for Injection is indicated for short-term treatment (7 to 10 days) of adult patients with gastroesophageal reflux disease (GERD) and a history of erosive esophagitis (EE). INDICATIONS AND USAGE-Treatment of Gastroesophageal Reflux Disease Associated With a History of Erosive Esophagitis: PROTONIX I.V. for Injection is indicated for short-term treatment (7 to 10 days) of patients with gastroesophageal reflux disease (GERD) and a history of erosive esophagitis. Pantoprazole 40 mg, powder for solution for injection should not be prepared or mixed with solvents other than those stated. In order to avoid risk of coring during needle insertion through the rubber stopper, a needle with an outside diameter of less than or equal to 0.8 mm should be used during preparation of the solution. Summary. Pantoprazole, brand name Protonix, is a drug that belongs to the class of drugs called proton pump inhibitors (PPIs). Protonix is used for the treatment of GERD (gastroesophageal reflux disease), stomach (peptic) and duodenum ulcers, and Zollinger-Ellison syndrome. Pantoprazole, first sold under the brand name Protonix, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome. Consumer information about the medication PANTOPRAZOLE - INJECTION (Protonix IV), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug PANTOPRAZOLE - INJECTION. Pantoprazole belongs to a class of drugs known as proton pump inhibitors (PPIs). The injection form of this drug is used for a short time when you cannot take the medication by mouth.